novel drug development for neuromuscular blockade
Clicks: 258
ID: 165271
2016
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Abstract
Pharmacological advances in anesthesia in recent decades have resulted in safer practice and better outcomes. These advances include improvement in anesthesia drugs with regard to efficacy and safety profiles. Although neuromuscular blockers were first introduced over a half century ago, few new neuromuscular blockers and reversal agents have come to market and even fewer have remained as common clinically employed medications. In recent years, newer agents have been studied and are presented in this review. With regard to nondepolarizer neuromuscular blocker agents, the enantiomers Gantacurium and CW002, which are olefinic isoquinolinium diester fumarates, have shown potential for clinical application. Advantages include ultra rapid reversal of neuromuscular blockade via cysteine adduction and minimal systemic hemodynamic effects with administration.
| Reference Key |
prabhakar2016journalnovel
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|---|---|
| Authors | ;Amit Prabhakar;Alan D Kaye;Melville Q Wyche;Orlando J Salinas;Kenneth Mancuso;Richard D Urman |
| Journal | molecular ecology resources |
| Year | 2016 |
| DOI |
10.4103/0970-9185.188833
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| URL | |
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