the role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

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ID: 164185
2016
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Abstract
Objective: Leptin reverses hyperglycemia in rodent models of type 1 diabetes (T1D). Direct application of leptin to the brain can lower blood glucose in diabetic rodents, and can activate autonomic efferents and non-shivering thermogenesis in brown adipose tissue (BAT). We investigated whether leptin reverses hyperglycemia through a mechanism that requires autonomic innervation, or uncoupling protein 1 (UCP1)-mediated thermogenesis. Methods: To examine the role of parasympathetic and sympathetic efferents in the glucose-lowering action of leptin, mice with a subdiaphragmatic vagotomy or 6-hydroxydopamine induced chemical sympathectomy were injected with streptozotocin (STZ) to induce hyperglycemia, and subsequently leptin treated. To test whether the glucose-lowering action of leptin requires activation of UCP1-mediated thermogenesis in BAT, we administered leptin in STZ-diabetic Ucp1 knockout (Ucp1−/−) mice and wildtype controls. Results: Leptin ameliorated STZ-induced hyperglycemia in both intact and vagotomised mice. Similarly, mice with a partial chemical sympathectomy did not have an attenuated response to leptin-mediated glucose lowering relative to sham controls, and showed intact leptin-induced Ucp1 expression in BAT. Although leptin activated BAT thermogenesis in STZ-diabetic mice, the anti-diabetic effect of leptin was not blunted in Ucp1−/− mice. Conclusions: These results suggest that leptin lowers blood glucose in insulin-deficient diabetes through a manner that does not require parasympathetic or sympathetic innervation, and thus imply that leptin lowers blood glucose through an alternative CNS-mediated mechanism or redundant target tissues. Furthermore, we conclude that the glucose lowering action of leptin is independent of UCP1-dependent thermogenesis. Author Video: Author Video Watch what authors say about their articles Keywords: Type 1 diabetes, Glucose, Vagotomy, Sympathectomy, Brown adipose tissue, Streptozotocin
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denroche2016molecularthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Heather C. Denroche, Michelle M. Kwon, Maria M. Glavas, Eva Tudurí, Marion Philippe, Whitney L. Quong, Timothy J. Kieffer
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Journal Small (Weinheim an der Bergstrasse, Germany)
Year 2016
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S2212877816300722
Keywords
internal medicine

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