insight into non-pathogenic th17 cells in autoimmune diseases

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ID: 163061
2018
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Abstract
Th17 cells are generally considered to be positive regulators of immune responses because they produce pro-inflammatory cytokines, including IL-17A, IL-17F, and IL-22. Cytokine production not only promotes accumulation of immune cells, such as macrophages, neutrophils and lymphocytes, at inflammatory sites but can also cause tissue pathologies. Conversely, certain Th17 cells can also negatively regulate immune responses by secreting immunosuppressive factors, such as IL-10; these cells are termed non-pathogenic Th17 cells. In this review, we summarize recent advances in the development and regulatory functions of non-pathogenic Th17 cells in autoimmune diseases.
Reference Key
wu2018frontiersinsight Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Xinyu Wu;Xinyu Wu;Jie Tian;Shengjun Wang;Shengjun Wang
Journal sudebno-meditsinskaia ekspertiza
Year 2018
DOI
10.3389/fimmu.2018.01112
URL
https://www.frontiersin.org/article/10.3389/fimmu.2018.01112/full
Keywords
inflammation immunosuppression il-10 th17 cells allergy

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