cardiac damage from chronic use of chloroquine: a case report and review of the literature
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ID: 162588
2002
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Abstract
Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up. Cardiac damage is not a common consequence, but its clinical relevance has not yet been described. We report the case of a 58-year-old woman with rheumatoid arthritis, in whom chronic chloroquine use resulted in major irreversible cardiac damage. She presented with syncopal episodes due to complete atrioventricular block confirmed by electrophysiological study whose changes were concluded to be irreversible and a permanent pacemaker was indicated. Endomyocardial biopsy was also performed to search for histopathological and ultrastructural cardiac damage. We also reviewed the 22 cases of chloroquine-induced cardiopathy described to date as well as its pathophysiology.
| Reference Key |
teixeira2002arquivoscardiac
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|---|---|
| Authors | ;Ricardo Alkmim Teixeira;Martino Martinelli Filho;Luiz Alberto Benvenuti;Roberto Costa;Anísio A. Pedrosa;Silvana A. D. Nishióka |
| Journal | revista cubana de ciencias informáticas |
| Year | 2002 |
| DOI |
10.1590/S0066-782X2002001000009
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| URL | |
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