research advances in drug resistance to nucleos(t)ide analogues in treatment of chronic hepatitis b

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ID: 162422
2015
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Abstract
Antiviral treatment is the key in the treatment of chronic hepatitis B. The long-term antiviral therapy with nucleos(t)ide analogues may lead to the viral gene mutations and drug resistance, and then the sensitivity of virus to the drug is decreased. In this study, the point mutations associated with four nucleos(t)ide analogues and the incidence of mutations were investigated. The rate of drug resistance to lamivudine was highest and that of resistance to entecavir was lowest. Recent research showed that hepatitis B virus (HBV) genotype was associated with drug resistance to nucleos(t)ide analogues. In order to prevent drug resistance, the indications for antiviral therapy should be determined strictly, and then the nucleos(t)ide analogues with high efficacy and low drug resistance can be selected. And if drug resistance develops, it is necessary to add or change to another nucleos(t)ide analogue without cross resistance.
Reference Key
xiu2015linchuangresearch Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;FAN Xiu
Journal lontar komputer
Year 2015
DOI
10.3969/j.issn.1001-5256.2015.04.033
URL
Keywords
hepatitis b Gastroenterology chronic; drug resistance; nucleosides; nucleotides; genotype; reviewdiseases of the digestive system

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