a spatially continuous model of carbohydrate digestion and transport processes in the colon.

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ID: 161180
2015
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Abstract
A spatially continuous mathematical model of transport processes, anaerobic digestion and microbial complexity as would be expected in the human colon is presented. The model is a system of first-order partial differential equations with context determined number of dependent variables, and stiff, non-linear source terms. Numerical simulation of the model is used to elucidate information about the colon-microbiota complex. It is found that the composition of materials on outflow of the model does not well-describe the composition of material in other model locations, and inferences using outflow data varies according to model reactor representation. Additionally, increased microbial complexity allows the total microbial community to withstand major system perturbations in diet and community structure. However, distribution of strains and functional groups within the microbial community can be modified depending on perturbation length and microbial kinetic parameters. Preliminary model extensions and potential investigative opportunities using the computational model are discussed.
Reference Key
moorthy2015plosa Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Arun S Moorthy;Stephen P J Brooks;Martin Kalmokoff;Hermann J Eberl
Journal ensaio pesquisa em educação em ciências
Year 2015
DOI
10.1371/journal.pone.0145309
URL
http://europepmc.org/articles/PMC4683063?pdf=render
Keywords
medicinescience

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