combination of strong mmp-2 and weak timp-2 immunostainings is a significant prognostic factor in endometrial carcinoma
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ID: 160955
2013
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Abstract
Objective. The aim of this study was to evaluate the combined effects of MMP-2 and TIMP-2 protein immunoreactivities on the prognosis in endometrial carcinoma.
Methods. Paraffin-embedded tissue samples from 225 primary endometrioid adenocarcinomas and 13 histologies other than endometrioid adenocarcinoma were immunohistochemically stained for MMP-2 and TIMP-2. Results. In Kaplan-Meier analysis, the 5-year cancer-specific survival rate of the endometrioid adenocarcinoma patients with negative MMP-2 and positive TIMP-2 staining was 100%, whereas only 78% of patients presenting with positive MMP-2 and negative TIMP-2 staining results were alive at that time. In Cox regression analysis, patients with positive MMP-2 and negative TIMP-2 immunostaining had a 4.7-fold relative risk of death from endometrial carcinoma compared to the group of patients with negative MMP-2 and positive or negative TIMP-2 immunoreaction. Conclusions. MMP-2 seems to be the main metalloproteinase determining the prognosis in endometrial carcinoma. Combination of strong MMP-2 and weak TIMP-2 immunostainings was the most potent prognostic marker for poor survival.
| Reference Key |
honkavuori-toivola2013diseasecombination
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| Authors | ;Maria Honkavuori-Toivola;Markku Santala;Ylermi Soini;Taina Turpeenniemi-Hujanen;Anne Talvensaari-Mattila |
| Journal | international journal of psychology : journal international de psychologie |
| Year | 2013 |
| DOI |
10.1155/2013/416870
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| URL | |
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