the n-terminal β-sheet of peroxiredoxin 4 in the large yellow croaker pseudosciaena crocea is involved in its biological functions.
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ID: 160858
2013
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Abstract
Peroxiredoxins (Prxs) are thiol-specific antioxidant proteins that exhibit peroxidase and peroxynitrite reductase activities involved in the reduction of reactive oxygen species. The peroxiredoxin Prx4 from the large yellow croaker Pseudosciaena crocea is a typical 2-Cys Prx with an N-terminal signal peptide. We solved the crystal structure of Prx4 at 1.90 Å and revealed an N-terminal antiparallel β-sheet that contributes to the dimer interface. Deletion of this β-sheet decreased the in vitro peroxidase activity to about 50% of the wild-type. In vivo assays further demonstrated that removal of this β-sheet led to some impairment in the ability of Prx4 to negatively regulate nuclear factor-κB (NF-κB) activity and to perform its role in anti-bacterial immunity. These results provide new insights into the structure and function relationship of a peroxiredoxin from bony fish.
| Reference Key |
mu2013plosthe
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|---|---|
| Authors | ;Yinnan Mu;Fu-Ming Lian;Yan-Bin Teng;Jingqun Ao;Yong-Liang Jiang;Yong-Xing He;Yuxing Chen;Cong-Zhao Zhou;Xinhua Chen |
| Journal | ensaio pesquisa em educação em ciências |
| Year | 2013 |
| DOI |
10.1371/journal.pone.0057061
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