roles of elevated intravitreal il-1β and il-10 levels in proliferative diabetic retinopathy

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ID: 160552
2014
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Abstract
Purpose: To determine the roles of interleukin (IL)-1β and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR). Materials and Methods: Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1β and IL-10 concentration in the vitreous was measured by using an enzyme-linked immunosorbent assay (ELISA). Results: Levels of IL-1β and IL-10 in vitreous were higher in PDR patients compared with control group. And there was significantly negative correlation between IL-1β and IL-10 in control group (r = −0.795; P = 0.032), whereas there was no significant correlation in PDR group (r = 0.176; P = 0.391). Conclusion: Levels of IL-1β and IL-10 were upregulated in vitreous of PDR patients, and these two cytokines play roles in regulating the development and progression of PDR.
Reference Key
mao2014indianroles Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Chunjie Mao;Hua Yan
Journal Bioinformatics
Year 2014
DOI
10.4103/0301-4738.136220
URL
http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=6;spage=699;epage=701;aulast=Mao
Keywords
Diabetic retinopathy immunology agreement intraocular pressure power interleukin-1β axial length interleukin-10 enzyme-linked immunosorbent assay accommodation hypertensive retinopathy lens twin pregnancy amplitude of accommodation

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