Simultaneous quantification of systemic azoles and their major metabolites in human serum by HPLC/PDA: role of azole metabolic rate.

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ID: 16043
2018
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Abstract
We describe the development and validation of a novel liquid chromatography assay (HPLC/PDA) for simultaneous quantification of voriconazole, itraconazole, and posaconazole, as well as some of their major metabolites, voriconazole N-oxide and hydroxy-itraconazole, in human serum. Analytes were detected using a PDA system that allows the characterization of the specific UV spectra of each compound. The assay exhibited linearity between 0.25-16 mg/L for all the compounds tested. The accuracy and within- and between-day precision of the assay were in acceptable ranges. We successfully quantified the azoles and some of their metabolites in a collection of clinical samples collected from treated patients. The method also allows assessing the metabolic rate of several azoles being useful to predict the metabolic profile of a particular patient and to anticipate toxicity or efficacy during the treatment.
Reference Key
gomezlopez2018simultaneousdiagnostic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gomez-Lopez, Alicia;Alcazar-Fuoli, Laura;Bernal-Martínez, Leticia;
Journal Diagnostic microbiology and infectious disease
Year 2018
DOI
S0732-8893(18)30116-0
URL
Keywords Keywords not found

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