determination of soluble icam-1 and tnfalphar in the cerebrospinal fluid and serum levels in a population of brazilian patients with relapsing-remitting multiple sclerosis determinação dos níveis de icam-1 e tnfalfar solúvel no líquido cefalorraqueano e soro numa população de pacientes brasileiros com esclerose múltipla forma surto-remissão

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ID: 160272
2001
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Abstract
Cytokines and adhesion molecules have been implicated in the pathogenesis of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system. In this study we analyzed intrathecal (CSF) and serum levels of soluble intercellular adhesion molecule (ICAM-1) and TNFalphaR (60kD) from 20 patients with clinically definite MS during acute relapse or stable disease. Comparing to control groups of healthy individuals and patients with intervertebral herniated disc, MS patients showed increased levels (p< 0.001) of sICAM-1 and TNFalphaR in both serum and CSF samples. Regardless stage of disease there was no significant difference in the levels of sICAM-1 during acute relapse (657±124.9 ng/ml) or remission (627±36.2 ng/ml). A steady increase of TNFalphaR (60kD) in both serum and CSF, indicate the existence of a continuous inflammatory process within the brain tissue of MS patients despite absence of clinical signs of disease activity.
Citocinas e moléculas de adesão estão implicadas na patogênese da esclerose múltipla (EM), uma doença inflamatória crônica do sistema nervoso central. Neste estudo, nós determinamos os níveis solúveis da molécula de adesão intercelular (sICAM-1) e TNFalfaR (60kD) no soro e líquido cefalorraqueano (LCR) de 20 pacientes com EM clinicamente definida durante surto ou remissão. Os pacientes com EM apresentaram, em comparação com os grupos controle formados por indivíduos sadios e com hérnia de disco intervertebral submetidos a mielografia, níveis significativamente (p< 0.001) elevados de sICAM-1 e TNFalfaR tanto no soro como no LCR. Independente do estágio da doença, nenhuma diferença significativa foi encontrada entre os pacientes durante o surto (657±124.9 ng/ml) ou na remissão (627±36.2 ng/ml). Um aumento consistente dos níveis de TNFalfaR no soro e LCR, apontam para a existência de processo inflamatório continuado no tecido cerebral dos pacientes com EM, a despeito da ausência de sinais clínicos de doença em atividade.
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alves-leon2001arquivosdetermination Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Soniza Vieira Alves-Leon;Elizabeth Batista;Regina Papais-Alvarenga;Thereza Quírico-Santos
Journal communications in computer and information science
Year 2001
DOI
10.1590/S0004-282X2001000100005
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000100005
Keywords
multiple sclerosis cytokines neuropsychiatry biological psychiatry intercellular adhesion molecule icam-1neurosciences

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