normal-phase thin-layer chromatography of some angiotensin converting enzyme (ace) inhibitors and their metabolites
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ID: 160221
2009
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Abstract
The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters RM0 and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography.
| Reference Key |
odovi2009journalnormal-phase
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| Authors | ;JADRANKA ODOVIĆ;MIRJANA ALEKSIĆ;BILJANA STOJIMIROVIĆ;DUŠANKA MILOJKOVIĆ-OPSENICA;ŽIVOSLAV TEŠIĆ |
| Journal | meditsinskaia radiologiia |
| Year | 2009 |
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