fetal origin of vascular aging

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ID: 159962
2011
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Abstract
Aging is increasingly regarded as an independent risk factor for development of cardiovascular diseases such as atherosclerosis and hypertension and their complications (e.g. MI and Stroke). It is well known that vascular disease evolve over decades with progressive accumulation of cellular and extracellular materials and many inflammatory processes. Metabolic syndrome, obesity and diabetes are conventionally recognized as risk factors for development of coronary vascular disease (CVD). These conditions are known to accelerate ageing process in general and vascular ageing in particular. Adverse events during intrauterine life may programme organ growth and favour disease later in life, popularly known as, ′Barker′s Hypothesis′. The notion of fetal programming implies that during critical periods of prenatal growth, changes in the hormonal and nutritional milieu of the conceptus may alter the full expression of the fetal genome, leading to permanent effects on a range of physiological.
Reference Key
pitale2011indianfetal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Shailesh Pitale;Anagha Sahasrabuddhe
Journal journal of physical chemistry a
Year 2011
DOI
10.4103/2230-8210.86971
URL
http://www.ijem.in/article.asp?issn=2230-8210;year=2011;volume=15;issue=8;spage=289;epage=297;aulast=Pitale
Keywords
atherosclerosis fetal programming Gastroenterology clinical endocrinologydiseases of the digestive system epigenetic transmission

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