s-palmitoylation regulates ampa receptors trafficking and function: a novel insight into synaptic regulation and therapeutics

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ID: 159523
2015
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Abstract
Glutamate acting on AMPA-type ionotropic glutamate receptor (AMPAR) mediates the majority of fast excitatory synaptic transmission in the mammalian central nervous system. Dynamic regulation of AMPAR by post-translational modifications is one of the key elements that allow the nervous system to adapt to environment stimulations. S-palmitoylation, an important lipid modification by post-translational addition of a long-chain fatty acid to a cysteine residue, regulates AMPA receptor trafficking, which dynamically affects multiple fundamental brain functions, such as learning and memory. In vivo, S-palmitoylation is controlled by palmitoyl acyl transferases and palmitoyl thioesterases. In this review, we highlight advances in the mechanisms for dynamic AMPA receptors palmitoylation, and discuss how palmitoylation affects AMPA receptors function at synapses in recent years. Pharmacological regulation of S-palmitoylation may serve as a novel therapeutic strategy for neurobiological diseases.
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han2015actas-palmitoylation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jun Han;Pengfei Wu;Fang Wang;Jianguo Chen
Journal energy policy
Year 2015
DOI
10.1016/j.apsb.2014.12.002
URL
http://www.sciencedirect.com/science/article/pii/S2211383514001233
Keywords
palmitoylation trafficking pharmacology dhhctherapeutics

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