isoniazid induced lupus presenting as oral mucosal ulcers with pancytopenia
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ID: 158782
2016
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Abstract
Drug Induced Lupus Erythematous (DILE) is a rare adverse reaction to a large variety of drugs including Isoniazid (INH), with features
resembling idiopathic Systemic Lupus Erythematosus (SLE). Diagnosis require identification of a temporal relationship between drug
administered and symptom. It is an idiosyncratic reaction, with no pre-existing lupus. Our case highlights a rare presentation of isoniazid
induced lupus with profound pancytopenia and mucosal ulcers, thus posing a diagnostic challenge. The patient was on multidrug
treatment for pulmonary and knee joint tuberculosis. DILE was diagnosed on basis of strongly positive Anti Nuclear Antibodies (ANA),
anti ds DNA and antihistone antibodies with clinical response to cessation of INH.
| Reference Key |
shah2016journalisoniazid
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|---|---|
| Authors | ;RIA SHAH;PADMARAJ ANKALE;KANISHK SINHA;APARNA IYER;T.K JAYALAKSHMI |
| Journal | JAMA network open |
| Year | 2016 |
| DOI |
10.7860/JCDR/2016/22543.8629
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| URL | |
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