autofocus methods of whole slide imaging systems and the introduction of a second-generation independent dual sensor scanning method

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ID: 158738
2011
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Abstract
Accurate focusing is a critical challenge of whole slide imaging, primarily due to inherent tissue topography variability. Traditional line scanning and tile-based scanning systems are limited in their ability to acquire a high degree of focus points while still maintaining high throughput. This review examines limitations with first-generation whole slide scanning systems and explores a novel approach that employs continuous autofocus, referred to as independent dual sensor scanning. This "second-generation" concept decouples image acquisition from focusing, allowing for rapid scanning while maintaining continuous accurate focus. The technical concepts, merits, and limitations of this method are explained and compared to that of a traditional whole slide scanning system.
Reference Key
montalto2011journalautofocus Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Michael C Montalto;Richard R McKay;Robert J Filkins
Journal annual review of materials science
Year 2011
DOI
10.4103/2153-3539.86282
URL
http://www.jpathinformatics.org/article.asp?issn=2153-3539;year=2011;volume=2;issue=1;spage=44;epage=44;aulast=Montalto
Keywords
digital pathology medical informaticspathology

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