click chemistry approach to a series of calcitriol analogues with heterocyclic side chains
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Abstract
We report a straightforward synthesis of a series of novel calcitriol analogues from vitamin D2with some modification of the procedures described by Calverley and Choudhry. This approach allows the large scale synthesis of a late-stage intermediate common to all the analogues of the series.This intermediate was successfully employed to synthesize a huge number of calcitriol analogues using a “click” chemistry approach.
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gndara2016mediterraneanclick
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| Journal | value in health : the journal of the international society for pharmacoeconomics and outcomes research |
| Year | 2016 |
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