microtubule organization in striated muscle cells

Clicks: 314
ID: 157485
2020
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Abstract
Distinctly organized microtubule networks contribute to the function of differentiated cell types such as neurons, epithelial cells, skeletal myotubes, and cardiomyocytes. In striated (i.e. skeletal and cardiac) muscle cells, the nuclear envelope acts as the dominant microtubule-organizing center (MTOC) and the function of the centrosome—the canonical MTOC of mammalian cells—is attenuated, a common feature of differentiated cell types. We summarize the mechanisms known to underlie MTOC formation at the nuclear envelope, discuss the significance of the nuclear envelope MTOC for muscle function and cell cycle progression, and outline potential mechanisms of centrosome attenuation.
Reference Key
becker2020cellsmicrotubule Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Robert Becker;Marina Leone;Felix B. Engel
Journal Frontiers in psychology
Year 2020
DOI
10.3390/cells9061395
URL
https://www.mdpi.com/2073-4409/9/6/1395
Keywords
centrosome skeletal muscle cardiomyocytes mtoc

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