cerebral hemodynamic and metabolic changes in fulminant hepatic failure

التغيرات الديناميكية الدموية والاستقلابية الدماغية في الفشل الكبدي الصاعق

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Abstract
ABSTRACT Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mechanism underlying cerebral edema and intracranial hypertension in the presence of FHF is multi-factorial in etiology and only partially understood. The aim of this paper is to review the pathophysiology of cerebral hemodynamic and metabolism changes in FHF in order to improve understanding of intracranial dynamics complication in FHF.
مستخلص: يُعد ارتفاع الضغط داخل القحف وتورم الدماغ سببًا رئيسيًا للمراضة والوفيات لدى المرضى الذين يعانون من الفشل الكبدي الخاطف (FHF). وقد جرى استقصاء الآلية الإمراضية لهذه المضاعفات لدى الإنسان، وفي النماذج التجريبية، وفي نظم الخلايا المعزولة. وحاليًا، تُعد الآلية الكامنة وراء الوذمة الدماغية وارتفاع الضغط داخل القحف المصاحبين للفشل الكبدي الخاطف متعددة العوامل سببيًا، ولا تزال مفهومة بصورة جزئية فقط. تهدف هذه الورقة البحثية إلى مراجعة الفيزيولوجيا المرضية لتغيرات الديناميكا الدموية والأيض الدماغي في الفشل الكبدي الخاطف؛ بغية تحسين فهم مضاعفات الديناميكا داخل القحف في هذا المرض.
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Authors Fernando Mendes Paschoal Junior, Ricardo de Carvalho Nogueira, Marcelo de Lima Oliveira, Eric Homero Albuquerque Paschoal, Manoel Jacobsen Teixeira, Luiz Augusto Carneiro D'Albuquerque, Edson Bor-Seng-Shu
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Journal communications in computer and information science
Year Year not found
DOI
10.1590/0004-282x20170076
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000700470&lng=en&tlng=en
Keywords
intracranial hypertension neuropsychiatry biological psychiatry

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