analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2h)-3-one derivatives
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ID: 156881
2013
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Abstract
Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema method for the evaluation of analgesic and anti-inflammatory activities, respectively. Results showed that compounds 4f, 4b, 4d, and 4e exhibited higher analgesic and anti-inflammatory activities than other remaining compounds. All title compounds (4a-f) were characterized by IR, NMR and Mass spectroscopy.
| Reference Key |
singh2013braziliananalgesic
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|---|---|
| Authors | ;Anita Singh;Lakshmayya;Mohammad Asif |
| Journal | electronic engineering times |
| Year | 2013 |
| DOI |
10.1590/S1984-82502013000400030
|
| URL | |
| Keywords | Keywords not found |
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