analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2h)-3-one derivatives

الأنشطة التسكينية والمضادة للالتهاب لعدة مشتقات من 4-مستبدل-6-(3'-نيتروفينيل)بيريدازين-(2H)-3-أون

Clicks: 138
ID: 156881
2013
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Abstract
Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema method for the evaluation of analgesic and anti-inflammatory activities, respectively. Results showed that compounds 4f, 4b, 4d, and 4e exhibited higher analgesic and anti-inflammatory activities than other remaining compounds. All title compounds (4a-f) were characterized by IR, NMR and Mass spectroscopy.
تم تخليق عدة مشتقات من 6-أريل-4-مستبدل بنزيليدين/فورفوريليدين بيريدازين (2H)-3-أون (4a-f) وتقييمها كعوامل مسكنة للألم ومضادة للالتهاب في الفئران والجرذان، على التوالي. واختُبرت جميع المركبات باستخدام طريقة الصفيحة الساخنة لإيدي وطريقة وذمة الطرف الخلفي المستحثة بالكاراجينان لتقييم الفعالية المسكنة للألم والمضادة للالتهاب، على التوالي. وأظهرت النتائج أن المركبات 4f و4b و4d و4e أبدت فعالية مسكنة ومضادة للالتهاب أعلى مقارنة ببقية المركبات الأخرى. كما تم توصيف جميع مركبات العنوان (4a-f) باستخدام مطيافية الأشعة تحت الحمراء (IR)، والرنين المغناطيسي النووي (NMR)، ومطيافية الكتلة (Mass spectroscopy).
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singh2013braziliananalgesic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Anita Singh, Lakshmayya, Mohammad Asif
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Journal electronic engineering times
Year 2013
DOI
10.1590/S1984-82502013000400030
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400030&lng=en&tlng=en
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