aspartic protease inhibitory and nematocidal activity of phenyl-4-(2-phenylhydrazono)hexahydrofuro[3,2-c]pyridazin-7-ol (percival dianhydroosazone)

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ID: 155901
2014
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Ranked #23 of 26 articles by views in value in health : the journal of the international society for pharmacoeconomics and outcomes research

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Abstract
We synthesized Phenyl-4-(2-phenylhydrazono)hexahydrofuro[3,2-c]pyridazin-7-ol (compound 3). The structure compound 3 was elucidated with IR, 1H NMR, 13C NMR and EIMS spectra. Compound 3 showed potent inhibitory activity against aspartic proteases, human cathepsin D and Plasmodium falciparum plasmepsin-II with IC50 = 20 μM. Enzyme-inhibitor complexes were predicted to stabilize by electrostatic and hydrophobic interactions between the side chains of amino acid residues at the active center and compound 3. Moreover, compound 3 displayed good nematocidal activity against all developmental stages of C. elegans.
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2014mediterraneanaspartic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
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Journal value in health : the journal of the international society for pharmacoeconomics and outcomes research
Year 2014
DOI
10.13171/mjc.3.2.2014.22.04.23
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