regulation of the dna methylation landscape in human somatic cell reprogramming by the mir-29 family

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ID: 155228
2016
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Abstract
Reprogramming to pluripotency after overexpression of OCT4, SOX2, KLF4, and MYC is accompanied by global genomic and epigenomic changes. Histone modification and DNA methylation states in induced pluripotent stem cells (iPSCs) have been shown to be highly similar to embryonic stem cells (ESCs). However, epigenetic differences still exist between iPSCs and ESCs. In particular, aberrant DNA methylation states found in iPSCs are a major concern when using iPSCs in a clinical setting. Thus, it is critical to find factors that regulate DNA methylation states in reprogramming. Here, we found that the miR-29 family is an important epigenetic regulator during human somatic cell reprogramming. Our global DNA methylation and hydroxymethylation analysis shows that DNA demethylation is a major event mediated by miR-29a depletion during early reprogramming, and that iPSCs derived from miR-29a depletion are epigenetically closer to ESCs. Our findings uncover an important miRNA-based approach to generate clinically robust iPSCs.
Reference Key
hysolli2016stemregulation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Eriona Hysolli;Yoshiaki Tanaka;Juan Su;Kun-Yong Kim;Tianyu Zhong;Ralf Janknecht;Xiao-Ling Zhou;Lin Geng;Caihong Qiu;Xinghua Pan;Yong-Wook Jung;Jijun Cheng;Jun Lu;Mei Zhong;Sherman M. Weissman;In-Hyun Park
Journal nature reviews gastroenterology & hepatology
Year 2016
DOI
10.1016/j.stemcr.2016.05.014
URL
http://www.sciencedirect.com/science/article/pii/S2213671116300698
Keywords
medicine (general)biology (general)

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