autophagy and ubiquitination in salmonella infection and the related inflammatory responses

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ID: 154817
2018
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Abstract
Salmonellae are facultative intracellular pathogens that cause globally distributed diseases with massive morbidity and mortality in humans and animals. In the past decades, numerous studies were focused on host defenses against Salmonella infection. Autophagy has been demonstrated to be an important defense mechanism to clear intracellular pathogenic organisms, as well as a regulator of immune responses. Ubiquitin modification also has multiple effects on the host immune system against bacterial infection. It has been indicated that ubiquitination plays critical roles in recognition and clearance of some invading bacteria by autophagy. Additionally, the ubiquitination of autophagy proteins in autophagy flux and inflammation-related substance determines the outcomes of infection. However, many intracellular pathogens manipulate the ubiquitination system to counteract the host immunity. Salmonellae interfere with host responses via the delivery of ~30 effector proteins into cytosol to promote their survival and proliferation. Among them, some could link the ubiquitin-proteasome system with autophagy during infection and affect the host inflammatory responses. In this review, novel findings on the issue of ubiquitination and autophagy connection as the mechanisms of host defenses against Salmonella infection and the subverted processes are introduced.
Reference Key
wang2018frontiersautophagy Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Lidan Wang;Jing Yan;Hua Niu;Rui Huang;Shuyan Wu
Journal electronic physician
Year 2018
DOI
10.3389/fcimb.2018.00078
URL
http://journal.frontiersin.org/article/10.3389/fcimb.2018.00078/full
Keywords
autophagy salmonella immune response effector protein ubiquitination virus replication

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