a preliminary study of recombinant human interferon-α-2a activity against rabies virus in murine model
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ID: 154053
2015
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Abstract
Rabies remains an important public health problem in the world due to uncontrolled enzootic rabies. Although rabies associated fatalities may be prevented with timely immunoprophylaxis, but till date a therapeutic molecule has remained elusive. We investigated the role of rhuIFN α-2a in murine model challenged with rabies virus. Titre of 10 4.25 LD 50 /0.03 ml of 10% w/v RV CVS stock suspension were obtained. Based on 1LD 50 titre, challenge dose of 50 LD 50 was administered along with rhuIFN α-2a with pre-exposure (primed) and post-exposure with the rabies virus. Both showed increased survival time as compared with the virus controls. These findings suggest that the rhuIFN α-2a might have some anti-viral activity, which can be used for the treatment of rabies infection. Further research on the efficacy of interferon along with anti-viral drugs for the treatment will be helpful in designing combination therapy against the disease.
| Reference Key |
roy2015indiana
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|---|---|
| Authors | ;S Roy;D Patil;S Ghadigaonkar;R Roy;S Mukherjee;A Chowdhary;R Deshmukh |
| Journal | bjog : an international journal of obstetrics and gynaecology |
| Year | 2015 |
| DOI |
10.4103/0255-0857.148412
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