clinical significance of 5αα-reductase and androgen receptor gene polymorphisms in prostate cancer
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Abstract
The development of prostate cancer is inseparably linked with the effect of androgens on the fundamental prostatic intracellular processes,such as proliferation, apoptosis, which is realized through a number of second messengers. Major of them are the AR gene encoding androgenreceptors and the SRD5A2 gene encoding 5α-reductase enzyme. This paper deals with the study of the role of these genes in prostate cancer.
| Reference Key |
loran2014onkourologiclinical
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| Authors | ;O. B. Loran;I. V. Lukyanov;D. Yu. Tuzov;A. N. Tyulpakov |
| Journal | supportive care in cancer |
| Year | 2014 |
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