a microrna/ubiquitin ligase feedback loop regulates slug-mediated invasion in breast cancer
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ID: 153073
2017
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Abstract
The transformation of a normal cell to cancer requires the derail of multiple pathways. Normal signaling in a cell is regulated at multiple stages by the presence of feedback loops, calibration of levels of proteins by their regulated turnover, and posttranscriptional regulation, to name a few. The tumor suppressor protein FBXO31 is a component of the SCF E3 ubiquitin ligase and is required to arrest cells at G1 following genotoxic stresses. Due to its growth-suppression activity, it is underexpressed in many cancers. However, the molecular mechanism underlying the translational regulation of FBXO31 remains unclear. Here we show that the oncogenic microRNAs miR-93 and miR-106a repress FBXO31, resulting in the upregulation of Slug, which is involved in epithelial-mesenchymal transition and cell invasion. FBXO31 targets and ubiquitylates Slug for proteasomal degradation. However, this mechanism is repressed in breast tumors where miR-93 and miR-106a are overexpressed. Our study further unravels an interesting mechanism whereby Slug drives the expression of miR-93 and miR-106a, thus establishing a positive feedback loop to maintain an invasive phenotype. Together, these results establish the presence of interplay between microRNAs and the ubiquitination machinery, which together regulate cancer cell invasion.
| Reference Key |
manne2017neoplasia:a
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| Authors | ;Rajesh Kumar Manne;Yashika Agrawal;Anil Bargale;Asha Patel;Debasish Paul;Neha Anilkumar Gupta;Srikanth Rapole;Vasudevan Seshadri;Deepa Subramanyam;Praveenkumar Shetty;Manas Kumar Santra |
| Journal | ACS chemical neuroscience |
| Year | 2017 |
| DOI |
10.1016/j.neo.2017.02.013
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| URL | |
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