transporte de secreções mucóides de indivíduos saudáveis e pacientes com doença pulmonar obstrutiva crónica e bronquiectasias

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ID: 152353
2013
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Abstract
Resumo: Objetivo: Analisar e comparar as propriedades de transporte in vitro da secreção respiratória de aspeto mucoide (M) de indivíduos sem doença respiratória e de pacientes com doença pulmonar obstrutiva crónica (DPOC) e bronquiectasias estáveis. Métodos: Foram avaliadas 21 amostras de indivíduos sem doença pulmonar submetidos a processos cirúrgicos, 10 amostras de pacientes com DPOC e 16 amostras de pacientes com bronquiectasias quanto ao transporte mucociliar (TMC), deslocamento na máquina simuladora de tosse (MST) e ângulo de contacto (AC). Resultados: Foi observado uma maior TMC das amostras de indivíduos sem doença respiratória (1,0 ± 0,19) quando comparado com o dos pacientes com DPOC (0,9 1± 0,17) e bronquiectasias (0,76 ± 0,23) (p < 0,05), enquanto que o deslocamento na MST foi maior nos pacientes com DPOC (16,31 ± 7,35 cm) quando comparado com o de pacientes com bronquiectasias (12,16 ± 6,64 cm) e de indivíduos sem doença respiratória (10,50 ± 25,8 cm) (p < 0,05). Não houve diferença envolvendo a avaliação do AC. Conclusão: O muco respiratório dos indivíduos saudáveis tem um melhor transporte ciliar do que o de pacientes com doenças respiratórias. No entanto, o muco de pacientes com DPOC tem uma melhor transportabilidade pela tosse, sugerindo que esses pacientes apresentam adaptações para tais mecanismos de defesa, enquanto que os pacientes com bronquiectasias têm deficiência no transporte ciliar, assim como no transporte pela tosse. Abstract: Objective: To characterise and compare the in vitro transport properties of respiratory mucoid secretion in individuals with no lung disease and in stable patients with chronic obstructive pulmonary disease (COPD) and bronchiectasis. Methodology: Samples of mucus were collected, from 21 volunteers presenting no lung disease who had undergone surgery, from 10 patients presenting chronic COPD, and from 16 patients with bronchiectasis. Mucociliary transport (MCT), transport by cough (SCM), and contact angle (CAM) were evaluated. Results: MCT was found to be greater in healthy individuals (1.0 ± 0.19) than in COPD (0.91 ± 0.17) and bronchiectasis (0.76 ± 0.23) patients (p < 0.05), whereas SCM was greater in COPD patients (16.31 ± 7.35 cm) than in patients with bronchiectasis (12.16 ± 6.64 cm) and healthy individuals (10.50 ± 25.8 cm) (p < 0.05). No significant differences were observed between the groups regarding CAM. Conclusion: Mucus from healthy individuals allows better mucociliary transport compared to that from patients with lung diseases. However, the mucus from COPD patients allows a better transport by coughing, demonstrating that these individuals have adapted to a defence mechanism compared to patients with bronchiectasis, who have impairment in their ciliary and cough transport mechanisms. Palavras-chave: DPOC, Bronquiectasia, Muco respiratório, Depuração mucociliar, Keywords: COPD, Bronchiectasis, Respiratory mucus, Mucociliary clearance
Reference Key
afonso2013revistatransporte Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;J. Lima Afonso;J. Tambascio;H.C. Dutra de Souza;J.R. Jardim;J.A. Baddini Martinez;A.C. Gastaldi
Journal the journal of applied psychology
Year 2013
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S0873215913000366
Keywords
diseases of the respiratory system

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