effect of tgf-β1 on epithelial mesenchymal transformation and invasion of choriocarcinoma cells
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ID: 152323
2016
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Abstract
Objective To explore the role of TGF-β1 on epithelial mesenchymal transformation and invasion by promoting cancer stem cell marker CD133 expression in choriocarcinoma cells. Method Choriocarcinoma cells JEG-3 were cultured in vitro and incubated with TGF-β1 at different time and concentration, and the expression of CD133 protein and mRNA of EMT markers were detected by Western blotting and PCR respectively. The effect of TGF-β1 on invasive ability of JEG-3 cells were assessed with transwell method. Results TGF-β1 promoted the expression of cancer stem cell marker CD133, downregulated the epithelial marker E-cadherin, upregulated mesenchymal marker N-cadherin, and promoted invasion ability in choriocarcinoma cells. Conclusion TGF-β1 could promote stem cell property of cancer, EMT property, and invasive property of choriocarcinoma cells.
DOI: 10.11855/j.issn.0577-7402.2016.02.06
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| Reference Key |
lu2016medicaleffect
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|---|---|
| Authors | ;Yan-jie LU;Shao-chen LIU;Ya-tao HU;Shu-ling ZHANG;Yan-zhen ZUO;Qian XU;Lei LIU;Yu-hong LI |
| Journal | frontiers in neurorobotics |
| Year | 2016 |
| DOI |
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| Keywords | Keywords not found |
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