the role of α-defensins 1–3 in antimicrobial protection forming in children with recurrent bronchitis caused by bacteria of the genus haemophilus

دور ديفنسينات ألفا 1–3 في تشكيل الحماية المضادة للميكروبات لدى الأطفال المصابين بالتهاب الشعب الهوائية المتكرر الناجم عن بكتيريا جنس المستدمية

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ID: 152292
2013
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Abstract
The level of α-defensins 1–3 (HNP 1–3) has been analyzed in the blood plasma of children with recurrent bronchitis caused by bacteria of the genus Haemophilus. It is shown that the level of HNP 1–3 in the blood plasma depends on the form of Haemophilus. Trigger of HNP 1–3 outflow for neutrophils was the presence of bacterial capsule while presence of L-forms of Haemophilus influenzae wasn’t associated with increase in synthesis of antimicrobial peptides that could be one of the factors of forming of Haemophilus antibiotic resistance.
جرى تحليل مستوى ديفنسينات ألفا 1–3 (HNP 1–3) في بلازما دم أطفال يعانون من التهاب الشعب الهوائية المتكرر الناجم عن بكتيريا من جنس المستدمية (Haemophilus). وتبيّن أن مستوى HNP 1–3 في بلازما الدم يعتمد على شكل بكتيريا المستدمية. وكان المحفز لتدفق HNP 1–3 من العدلات هو وجود المحفظة البكتيرية، في حين لم يرتبط وجود الأشكال-L (L-forms) لبكتيريا المستدمية النزلية (Haemophilus influenzae) بزيادة في تخليق الببتيدات المضادة للميكروبات، وهو ما قد يمثل أحد العوامل في تشكّل مقاومة المستدمية للمضادات الحيوية.
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lezhenko2013zdorovethe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors G.O. Lezhenko, O.Ye. Abaturov, O.Ye. Pashkova, L.I. Pantyushenko
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Journal scientific electronic archives
Year 2013
DOI
10.22141/2224-0551.2.45.2013.88021
URL
http://childshealth.zaslavsky.com.ua/article/view/88021
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