profile of tumour necrosis factor alpha -308 g/a gene polymorphism in psoriatic patients in karnataka, india
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2017
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Abstract
Introduction: Tumour necrosis factor-alpha (TNFα) gene -308G/A
polymorphism (rs1800629) are associated with psoriasis in
several populations worldwide. Presently, there is no literature on
the status of this polymorphism in the South Indian population.
Aim: To determine the profile of TNFα -308G/A polymorphism
among psoriatic patients.
Materials and Methods: This case-control study involved 74
patients with Psoriasis Vulgaris (PsV) and 74 age and gender
matched healthy individuals. Patients were recruited from
the Department of Dermatology of R.L. Jalappa Hospital
and Research Center, Tamaka, Kolar, Karnataka, India, from
March 2014 to March 2016. TNFα -308G/A polymorphism was
genotyped by Polymerase Chain Reaction-Restriction Fragment
Length Polymorphism (PCR-RFLP) method.
Results: The frequency of TNFα -308A allele 7.4% among
psoriatic and 8.8% among non-psoriatic individuals. The
difference was not statistically significant (p=0.82).
Conclusion: Our results indicate that TNFα gene -308G/A
polymorphism is not a significant marker for the risk of developing
PsV among South Indian (Karnataka) psoriatic patients.
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|---|---|
| Authors | ;Deepa Rajesh;Chaitra Chowdappa;Rajesh Gurumurthy;A.V. Moideen Kutty;Sharath Balakrishna |
| Journal | JAMA network open |
| Year | 2017 |
| DOI |
10.7860/JCDR/2017/24909.9411
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