internalization of staphylococcus aureus in lymphocytes induces oxidative stress and dna fragmentation: possible ameliorative role of nanoconjugated vancomycin

Tiklamalar: 226
ID: 152219
2011
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Staphylococcus aureus is the most frequently isolated pathogen causing bloodstream infections, skin and soft tissue infections and pneumonia. Lymphocyte is an important immune cell. The aim of the present paper was to test the ameliorative role of nanoconjugated vancomycin against Vancomycin-sensitive Staphylococcus aureus (VSSA) and vancomycin-resistant Staphylococcus aureus (VRSA) infection-induced oxidative stress in lymphocytes. VSSA and VRSA infections were developed in Swiss mice by intraperitoneal injection of 5×106 CFU/mL bacterial solutions. Nanoconjugated vancomycin was adminstrated to VSSA- and VRSA-infected mice at its effective dose for 10 days. Vancomycin was adminstrated to VSSA- and VRSA-infected mice at a similar dose, respectively, for 10 days. Vancomycin and nanoconjugated vancomycin were adminstrated to normal mice at their effective doses for 10 days. The result of this study reveals that in vivo VSSA and VRSA infection significantly increases the level of lipid peroxidation, protein oxidation, oxidized glutathione level, nitrite generation, nitrite release, and DNA damage and decreases the level of reduced glutathione, antioxidant enzyme status, and glutathione-dependent enzymes as compared to control group, which were increased or decreased significantly near to normal in nanoconjugated vancomycin-treated group. These findings suggest the potential use and beneficial role of nanoconjugated vancomycin against VSSA and VRSA infection-induced oxidative stress in lymphocytes.
Referans Anahtari
chakraborty2011oxidativeinternalization Kullanarak makale yazarken otomatik alinti icin bu anahtari kullanin SciMatic Makale Yoneticisi veya Tez Yoneticisi
Yazarlar Subhankari Prasad Chakraborty, Santanu Kar Mahapatra, Sumanta Kumar Sahu, Sabyasachi Das, Satyajit Tripathy, Sandeep Dash, Panchanan Pramanik, Somenath Roy
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Dergi journal of aoac international
Yil 2011
DOI
10.1155/2011/942123
URL
http://dx.doi.org/10.1155/2011/942123
Anahtar Kelimeler
cytology

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