adherence to treatment with imatinib in chronic myeloid leukemia: a study of the first decade of responses obtained at a brazilian hospital
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2013
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Abstract
Objetive: The aim of this study was to identify the reasons for failure in adherence to imatinib mesylate treatment in chronic myeloid leukemia. Methods: A retrospective review was performed of 100 non-electronic records of patients with Ph+ chronic myeloid leukemia treated with imatinib mesylate. The study period was from January 2001 to January2011. Data were analyzed by Chi-Square and Correspondence analysis using the Statistical Analysis System software package. Results: At the beginning of treatment 41% of patients were in advanced stages of the disease. The unavailability of the drug (44.8%) and myelotoxicity (25.7%) were the most frequent reasons for interruption. The adherence rate was < 90% in 47% of the cases. The low adherence influenced the cytogenetic response (p-value = 0.020) and molecular response (p-value = 0.001). Very high adherence (> 95%) induced complete cytogenetic response, major cytogenetic response and major molecular response. Conclusion: The population of this study obtained lower-than-expected therapeutic responses compared to other studies.
| Reference Key |
reis2013revistaadherence
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| Authors | ;Samuel Roosevelt Campos dos Reis;Acy Telles de Souza Quixada;Sammara Tavares Nunes;Danielle Maria Camelo Cid;Jacqueline Holanda de Souza;Clara Maria Bastos Eloy da Costa;Carolina Bizelli Silveira;David Antonio Camelo Cid;Mariana Fatima Cabral de Oliveira |
| Journal | journal of computational and graphical statistics : a joint publication of american statistical association, institute of mathematical statistics, interface foundation of north america |
| Year | 2013 |
| DOI |
10.5581/1516-8484.20130053
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| URL | |
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