preditores de função ventricular esquerda global na síndrome metabólica predictores de función ventricular izquierda global en el síndrome metabólico predictors of global left ventricular function in metabolic syndrome
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Abstract
FUNDAMENTO: El síndrome metabólico (SM) representa un conjunto de factores de riesgo cardiovascular que actúan de forma sinérgica. OBJETIVO: El objetivo de este estudio fue determinar cuales parámetros estaban asociados de forma independiente a la función global del ventrículo izquierdo (VI) en individuos con SM, estimada a través del índice Tei. MÉTODOS: El estudio incluyó 234 individuos con SM y 96 controles ajustados por edad. El SM fue definido por la presencia de tres o más criterios ATP-NCEP III. Todos los individuos fueron sometidos a tests de laboratorio y ecocardiograma bidimensional y con Doppler pulsado y tisular. Intervalos de tiempo apropiados en el Doppler tisular para la estimativa del índice Tei también fueron evaluados. RESULTADOS: El índice Tei estaba aumentado en todos los individuos con SM (0,35 ± 0,05 vs 0,49 ± 0,10, p < 0,001). Análisis de regresión múltiple de los parámetros clínicos mostró que la presión arterial sistólica (β = 0,289, p < 0,001), glucemia de ayuno (β = 0,205, p = 0,009), índice de masa del VI (β = 0,301, p < 0,001), E/e'septal (β = 0,267, p < 0,001) y e'septal (β = -0,176, p = 0,011) estaban independientemente asociados con la función ventricular izquierda global estimada por el índice Tei. CONCLUSIÓN: El SM tuvo un impacto significativo en la función global del VI. La presión arterial sistólica, glucemia de ayuno, índice de masa del VI E/e'septal, y e'septal estaban independientemente asociados con la función global del VI. (Arq Bras Cardiol 2011;96(5):377-385)
BACKGROUND: The metabolic syndrome (MS) represents a cluster of cardiovascular risk factors that act synergistically. OBJECTIVE: The aim of this study was to determine which parameters were independently associated with the global left ventricular (LV) function in subjects with MS estimated with the Tei index. METHODS: The study included 234 subjects with MS and 96 controls adjusted by age. MS was defined by the presence of three or more of ATP- NCEP III criteria. All subjects underwent laboratory blood tests and two-dimensional, pulsed and tissue Doppler echocardiography. Appropriate tissue Doppler time intervals for the estimation of the Tei index were also assessed. RESULTS: The Tei index was increased in subjects with MS (0.35 ± 0.05 vs 0.49 ± 0.10, p < 0.001). Multiple regression analysis of the clinical parameters showed that systolic blood pressure (β= 0.289, p < 0.001), fasting glucose (β= 0.205, p = 0.009), LV mass index (β= 0.301, p < 0.001), E/e'septal (β= 0.267, p < 0.001), and e'septal (β= -0.176, p = 0.011) were independently associated with the global left ventricular function estimated by Tei index. CONCLUSION: MS has a significant impact on LV global function. Systolic blood pressure, fasting glucose, LV mass index, E/e'septal, and e'septal were independently associated with the LV global function.
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ivanovic2011arquivospreditores
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| Authors | ;Branislava Aleksa Ivanovic;Marijana Vaso Tadic;Dragan Vojislav Simic |
| Journal | revista cubana de ciencias informáticas |
| Year | 2011 |
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