clinical efficacy of lamotrigien in combined with valproic acid in the treatment of epilepsy

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ID: 149891
2016
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Abstract
Objective: To observe the clinical efficacy of lamotrigien (LTG) in combined with valproic acid (VAP) in the treatment of epilepsy and their effects on lipid metabolism indicators and recognition function. Methods: A total of 80 patients with epilepsy who were admitted in our hospital from January, 2014 to January, 2015 were included in the study and randomized into the observation group and the control group with 30 cases in each group. The patients in the observation group were given LTG in combined with VAP, while the patients in the control group were only given VAP. The clinical efficacy in the two groups was compared. Changes of various lipid indicators and recognition function in the two groups were detected. Results: The total effective rate in the observation group was significantly higher than that in the control group. The attentiveness, memory delay, and MOCA score after treatment in the observation group were significantly elevated when compared with before treatment, and were significantly higher than those in the control group. The comparison of implementing competence before and after treatment in the observation group was not statistically significant . The levels of TC, TG, LDL-C, and HDL-C after treatment in the observation group were not significantly different from those before treatment. The levels of TC, TG, and LDL-C after treatment in the control group were significantly elevated when compared with before treatment and were significantly higher than those in the observation group in the same period. Conclusions: LTG in combined with VAP can effectively control the seizure frequency in patients with epilepsy with a small effect on lipid metabolism, and significantly improve the cognition ability; therefore, it deserves to be widely recommended in the clinic.
Reference Key
wen2016journalclinical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yu-Mei Wen;Xiu-Juan Liu;Xiao-Yu Liu;Ming-Xia Xu
Journal journal of communications
Year 2016
DOI
DOI not found
URL
http://www.hnykdxxb.com/PDF/201608/26.pdf
Keywords
epilepsy

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