efficacy of botulinum toxin b injection for raynaud’s phenomenon and digital ulcers in patients with systemic sclerosis
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2017
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Abstract
The efficacy and safety of botulinum toxin B (BTX-B) for treatment of Raynaud’s phenomenon and digital ulcers in patients with systemic sclerosis was assessed. A total of 45 patients with systemic sclerosis who had Raynaud’s phenomenon were blinded and divided randomly into 4 groups: a no-treatment control group, and 3 treatment groups, using 250, 1,000 or 2,000 international units (U) of BTX-B injections in the hand with more severe symptoms. Four weeks after injection, pain/numbness visual analogue scale scores and Raynaud’s score in the groups treated with 1,000 and 2,000 U BTX-B were significantly lower than in the control group and the group treated with 250 U BTX-B. These beneficial effects were sustained until 16 weeks after the single injection. At 4 weeks after injection skin temperature recovery in the group treated with 2,000 U BTX-B was significantly improved. The numbers of digital ulcers in the groups treated with 1,000 and 2,000 U BTX-B were significantly lower than in the control group. In conclusion, 1,000 and 2,000 U BTX-B injections significantly suppressed the activity of Raynaud’s phenomenon and digital ulcers in patients with SSc without serious adverse events.
| Reference Key |
motegi2017actaefficacy
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|---|---|
| Authors | ;Sei-ichiro Motegi;Akihito Uehara;Kazuya Yamada;Akiko Sekiguchi;Chisako Fujiwara;Sayaka Toki;Yuki Date;Tetsuya Nakamura;Osamu Ishikawa |
| Journal | renewable energy technologies for water desalination |
| Year | 2017 |
| DOI |
10.2340/00015555-2665
|
| URL | |
| Keywords | Keywords not found |
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