Generation of two spinal muscular atrophy (SMA) type I patient-derived induced pluripotent stem cell (iPSC) lines and two SMA type II patient-derived iPSC lines.

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ID: 14761
2019
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Abstract
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by deletion or mutation in SMN1 gene. SMA human induced pluripotent stem cells (iPSCs) represent a useful and valid model for the study of the disorder, as they provide in vitro the target cells. We generated iPSCs from a SMA type I patient and SMA type II patient by using non-integrating episomal plasmid vectors. The resulting iPSCs are episomal-free, express pluripotency markers, display a normal karyotype, retain the mutation (homozygous deletion of SMN1) and are able to differentiate into the three germ layers.
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valetdinova2019generationstem Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Valetdinova, K R;Maretina, M A;Kuranova, M L;Grigor'eva, E V;Minina, Y M;Kizilova, E A;Kiselev, A V;Medvedev, S P;Baranov, V S;Zakian, S M;
Journal Stem cell research
Year 2019
DOI
S1873-5061(18)30311-8
URL
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