back to the fusion: mitofusin-2 in alzheimer’s disease

Clicks: 273
ID: 147171
2020
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Abstract
Mitochondria are dynamic organelles that undergo constant fission and fusion. Mitochondria dysfunction underlies several human disorders, including Alzheimer’s disease (AD). Preservation of mitochondrial dynamics is fundamental for regulating the organelle’s functions. Several proteins participate in the regulation of mitochondrial morphology and networks, and among these, Mitofusin 2 (Mfn2) has been extensively studied. This review focuses on the role of Mfn2 in mitochondrial dynamics and in the crosstalk between mitochondria and the endoplasmic reticulum, in particular in AD. Understanding how this protein may be related to AD pathogenesis will provide essential information for the development of therapies for diseases linked to disturbed mitochondrial dynamics, as in AD.
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sita2020journalback Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Giulia Sita;Patrizia Hrelia;Agnese Graziosi;Fabiana Morroni
Journal international journal of occupational medicine and environmental health
Year 2020
DOI
10.3390/jcm9010126
URL
https://www.mdpi.com/2077-0383/9/1/126
Keywords
alzheimer’s disease endoplasmic reticulum

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