development of oral sustained release rifampicin loaded chitosan nanoparticles by design of experiment

Cliques: 397
ID: 146926
2013
PDF Gratuito
Metricas de Qualidade e Desempenho do Artigo
Qualidade Geral Improving Quality
0.0 /100
Combina dados de engajamento com qualidade academica avaliada por IA
Avaliacao de Qualidade por IA
Nao analisado
Resumo
Objective. The main objective of the present investigation was to develop and optimize oral sustained release Chitosan nanoparticles (CNs) of rifampicin by design of experiment (DOE). Methodology. CNs were prepared by modified emulsion ionic gelation technique. Here, inclusion of hydrophobic drug moiety in the hydrophilic matrix of polymer is applied for rifampicin delivery using CN. The 23 full-factorial design was employed by selecting the independent variables such as Chitosan concentration (X1), concentration of tripolyphosphate (X2), and homogenization speed (X3) in order to achieve desired particle size with maximum percent entrapment efficiency and drug loading. The design was validated by checkpoint analysis, and formulation was optimized using the desirability function. Results. Particle size, drug entrapment efficiency, and drug loading for the optimized batch were found to be 221.9 nm, 44.17 ± 1.98% W/W, and 42.96 ± 2.91% W/W, respectively. In vitro release data of optimized formulation showed an initial burst followed by slow sustained drug release. Kinetic drug release from CNs was best fitted to Higuchi model. Conclusion. Design of Experiment is an important tool for obtaining desired characteristics of rifampicin loaded CNs. In vitro study suggests that oral sustained release CNs might be an effective drug delivery system for tuberculosis.
Chave de Referencia
patel2013journaldevelopment Use esta chave para citacao automatica no manuscrito ao usar SciMatic Gerenciador de Manuscritos ou Gerenciador de Teses
Autores ;Bhavin K. Patel;Rajesh H. Parikh;Pooja S. Aboti
Periodico linux dev center, downloaded from http://www linuxdevcenter com/lpt/a/1636
Ano 2013
DOI
10.1155/2013/370938
URL
http://dx.doi.org/10.1155/2013/370938
Palavras-chave
chemistry Pharmacy and materia medica Rutin standardization quercetin phytochemical analysis hptlc critical care first aid intensive care

Citacoes

Nenhuma citacao encontrada. Para adicionar uma citacao, entre em contato com o administrador em info@scimatic.org

Comentarios

Nenhum comentario ainda. Seja o primeiro a comentar neste artigo.