treatment of middle ear ventilation disorders: sheep as animal model for stenting the human eustachian tube--a cadaver study.

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ID: 146881
2014
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Abstract
Eustachian tube disorders can lead to chronic otitis media with consecutive conductive hearing loss. To improve treatment and to develop new types of implants such as stents, an adequate experimental animal model is required. As the middle ear of sheep is known to be comparable to the human middle ear, the dimensions of the Eustachian tube in two strains of sheep were investigated. The Eustachian tube and middle ear of half heads of heathland and blackface sheep were filled with silicone rubber, blended with barium sulfate to induce X-ray visibility. Images were taken by digital volume tomography. The tubes were segmented, and a three-dimensional model of every Eustachian tube was generated. The lengths, diameters and shapes were determined. Additionally, the feasibility of endoscopic stent implantation and fixation was tested in cadaver experiments. The length of the tube between ostium pharyngeum and the isthmus and the diameters were comparable to published values for the human tube. The tube was easily accessible through the nose, and then stents could be implanted and fixed at the isthmus. The sheep appears to be a promising model for testing new stent treatments for middle ear ventilation disorders.
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miller2014plostreatment Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Felicitas Miller;Alice Burghard;Rolf Salcher;Verena Scheper;Wolfgang Leibold;Thomas Lenarz;Gerrit Paasche
Journal ensaio pesquisa em educação em ciências
Year 2014
DOI
10.1371/journal.pone.0113906
URL
https://doi.org/10.1371/journal.pone.0113906
Keywords
medicinescience

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