Total synthesis and evaluation of 8-deoxypumiliotoxin 193H.

Clicks: 231
ID: 1468
2019
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Abstract
The total synthesis of both the double bond isomers of indolizine alkaloid 8-deoxypumiliotoxin 193H has been accomplished. Both the double bond isomers Z-4 and E-4 induced convulsions and inhibited neuro-muscular activity at a dose of 25 mg/kg after intraperitoneal injection in mice. The lethal dose of Z-4 and E-4 was 100 mg/kg, indicating that 8-deoxypumiliotoxin 193H is 10-times less toxic than the known pumiliotoxin (+)-251 D.
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zvejniece2019total Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zvejniece, Liga;Dambrova, Maija;Smits, Gints;
Journal Natural product research
Year 2019
DOI
10.1080/14786419.2019.1636244
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