nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of wistar rats
Clicks: 307
ID: 146613
2011
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Star Article
30.0
/100
307 views
31 readers
AI Quality Assessment
Not analyzed
Readership in this journal
StarRanked #21 of 186 articles by views in nonlinear analysis: real world applications
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 186 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Dadong Han1, Yutao Tian2, Tao Zhang2, Guogang Ren3, Zhuo Yang11School of Medicine, The Key Laboratory of Bioactive Materials, Ministry of Education, 2College of Life Science, Nankai University, Tianjin, China; 3Science and Technology Research Institute, University of Hertfordshire, Hatfield, Hertfordshire, UKAbstract: This study focused on the effects of zinc oxide nanoparticles (nano-ZnO) on spatial learning and memory and synaptic plasticity in the hippocampus of young rats, and tried to interpret the underlying mechanism. Rats were randomly divided into four groups. Nano-ZnO and phosphate-buffered saline were administered in 4-week-old rats for 8 weeks. Subsequently, performance in Morris water maze (MWM) was determined, and then long-term potentiation (LTP) and depotentiation were measured in the perforant pathway to dentate gyrus (DG) in anesthetized rats. The data showed that, (1) in MWM, the escape latency was prolonged in the nano-ZnO group and, (2) LTP was significantly enhanced in the nano-ZnO group, while depotentiation was barely influenced in the DG region of the nano-ZnO group. This bidirectional effect on long-term synaptic plasticity broke the balance between stability and flexibility of cognition. The spatial learning and memory ability was attenuated by the alteration of synaptic plasticity in nano-ZnO-treated rats.Keywords: zinc oxide nanoparticles, synaptic plasticity, long-term potentiation, depotentiation, spatial learning, memory
| Reference Key |
d2011internationalnano-zinc
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Han D;Tian Y;Zhang T;Ren G;Yang Z |
| Journal | nonlinear analysis: real world applications |
| Year | 2011 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.