dosimetry study of different irradiation technologies for patients with recurrence of cervical cancer

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ID: 146498
2011
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Abstract
Objective To compare the dosimetric characteristics of intensity-modulated radiation therapy(IMRT),three-dimensional conformal radiation therapy(3D-CRT) and super gamma knife arc conformal radiotherapy(SGS-CRT) for patients with recurrence of cervical cancer.Methods Treatment planning of IMRT,3D-CRT and SGS-CRT for 15 patients with recurrence of cervical cancer was designed,and the prescription dose(50Gy,2.0Gy×25) covered 95% of the planning target volume(PTV).The dosimetric characteristics of the 3 irradiation technologies in target region and organs at risk were compared by analyzing dose-volume histogram(DVH).Results The target volume of 95% prescription dose was significantly higher in 3D-CRT(99.9%±0.2%) than in IMRT(99.5%±0.5%) and SGS-CRT(99.3%±0.8%,P < 0.05);the dose gradient of target region was significantly higher in SGS-CRT(85%±20%) than in IMRT(10%±7%) and 3D-CRT(8%±5%,P < 0.05);the conformal index of target region was higher in IMRT(0.9±0.3) than in SGS-CRT(0.8±0.2,P < 0.05),and the latter was higher than that in 3D-CRT(0.7±0.5,P < 0.05).The DVH showed that the radiation volumes of bladder was lower in SGS-CRT(27.8%) than in IMRT(40.1%) and 3D-CRT(57.4%,P < 0.05) when the dosage ranged from 10 to 30 Gy,and the radiation volumes of rectum was lower in SGS-CRT(25.4%) than in IMRT(48.9%) and 3D-CRT(73.2%,P < 0.05) when the dosage ranged from 5 to 45 Gy,while there was no significant difference among the 3 irradiation technologies of the radiation volumes of small bowel.Conclusion SGS-CRT shows some dosimetric advantages in treating patients with recurrence of cervical cancer.
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Authors ;Jian NING;Xiao-feng MU;Jie BU;Shu-ming YANG;Wei-dong ZHAO
Journal frontiers in neurorobotics
Year 2011
DOI
DOI not found
URL
http://www.plamj.org/index.php/plamj/article/view/228
Keywords Keywords not found

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