early cortical changes in gamma oscillations in alzheimer’s disease
Clicks: 294
ID: 146058
2016
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
30.0
/100
294 views
42 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #55 of 133 articles by views in Vacuum
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 133 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
The entorhinal cortices in the temporal lobe of the brain are key structures relaying memory related information between the neocortex and the hippocampus. The medial entorhinal cortex (MEC) routes spatial information whereas the lateral entorhinal cortex (LEC) routes predominantly olfactory information to the hippocampus. Gamma oscillations are known to coordinate information transfer between brain regions by precisely timing population activity of neuronal ensembles. Here we studied the organization of in vitro gamma oscillations in the MEC & LEC of the transgenic (tg) APP-PS1 mouse model of Alzheimer’s Disease (AD) at 4 – 5 months of age. In vitro gamma oscillations using the kainate model peaked between 30 - 50 Hz and therefore we analyzed the oscillatory properties in the 20 – 60 Hz range. Our results indicate that the LEC shows clear alterations in frequency and power of gamma oscillations early-on in AD as compared to the MEC. The gamma-frequency oscillation slows down in the LEC and also the gamma power in dorsal LEC is decreased as early as 4 – 5 months in the tg APP-PS1 mice. The results of this study suggest that the timing of olfactory inputs from LEC to the hippocampus might be affected early on in AD, resulting in a possible erroneous integration of the information carried by the two input pathways to the hippocampal subfields.
| Reference Key |
klein2016frontiersearly
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Alexandra Klein;Alexandra Klein;José R. Donoso;José R. Donoso;Richard Kempter;Richard Kempter;Dietmar Schmitz;Dietmar Schmitz;Dietmar Schmitz;Dietmar Schmitz;Dietmar Schmitz;Prateep Beed;Prateep Beed;Prateep Beed |
| Journal | Vacuum |
| Year | 2016 |
| DOI |
10.3389/fnsys.2016.00083
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.