mechanisms of cryptococcus neoformans-mediated host damage

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ID: 145577
2018
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Abstract
Cryptococcus neoformans is not usually considered a cytotoxic fungal pathogen but there is considerable evidence that this microbe can damage host cells and tissues. In this essay, we review the evidence that C. neoformans damages host cells and note that the mechanisms involved are diverse. We consider C. neoformans-mediated host damage at the molecular, cellular, tissue, and organism level. Direct mechanisms of cytotoxicity include lytic exocytosis, organelle dysfunction, phagolysosomal membrane damage, and cytoskeletal alterations. Cytotoxicity contributes to pathogenesis by interfering with immune effector cell function and disrupting endothelial barriers thus allowing dissemination. When C. neoformans-mediated and immune-mediated host damage is sufficient to affect homeostasis, cryptococcosis occurs at the organism level.
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casadevall2018frontiersmechanisms Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Arturo Casadevall;Carolina Coelho;Alexandre Alanio;Alexandre Alanio;Alexandre Alanio
Journal sudebno-meditsinskaia ekspertiza
Year 2018
DOI
10.3389/fimmu.2018.00855
URL
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00855/full
Keywords
cryptococcosis macrophage damage disease cryptococcus allergy

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