associação entre doença hepática gordurosa não alcoólica e marcadores de lesão/função hepática com componentes da síndrome metabólica em indivíduos obesos classe iii association between non-alcoholic fatty liver disease and liver function/injury markers with metabolic syndrome components in class iii obese individuals

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ID: 144406
2012
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Abstract
OBJETIVO: Investigar a associação entre doença hepática gordurosa não alcoólica (DHGNA) e os marcadores de lesão e função hepática com os componentes da síndrome metabólica (SM) em indivíduos obesos classe III. MÉTODOS: A população estudada foi constituída por 144 pacientes com obesidade classe III (IMC > a 40 kg/m²). A SM foi identificada segundo o critério do NCEP ATP III, por meio da determinação do perfil lipídico, glicemia e insulina basal. Foram quantificados ainda os marcadores de função e lesão hepática. A resistência à insulina (RI) foi verificada pelo índice HOMA-IR e o diagnóstico da DHGNA por ressonância magnética. Os cálculos estatísticos foram realizados pelo programa estatístico SPSS na versão 13.0. A associação foi verificada pelo teste Mann-Whitney e qui-quadrado, com nível de significância de 5%. RESULTADOS: Foi encontrada associação significativa entre o diagnóstico de SM e DHGNA (χ² = 6,84; p = 0,01). Quanto aos componentes diagnósticos para SM, constatou-se associação positiva e significativa entre HDL-c (p = 0,05), circunferência da cintura (p < 0,05) e hipertensão arterial (χ² = 4,195; p = 0,041) com a DHGNA. O índice HOMA-IR (p < 0,001) também apresentou associação positiva com a doença hepática. CONCLUSÃO: Constatouse associação positiva e significativa entre DHGNA e componentes da SM em indivíduos obesos classe III, sugerindo a necessidade e importância do monitoramento desses componentes para rastreamento da DHGNA.
OBJECTIVE: To investigate the association between non-alcoholic fatty liver disease (NAFLD) and liver function/injury markers with components of metabolic syndrome (MS) in class III obese individuals. METHODS: The study population consisted of 144 patients with class III obesity (body mass index [BMI] > 40 kg/m²). MS was diagnosed according to the National Cholesterol Education Program - Adult Treatment Panel III (NCEP ATP III) criteria, by determining the lipid profile, blood glucose and basal insulin. Liver function/injury markers were also quantified. Insulin resistance (IR) was measured by HOMA-IR and NAFLD diagnosis was established by magnetic resonance imaging (MRI). Statistical calculations were performed by SPSS version 13.0. The association was assessed by the Mann-Whitney and Chi-square tests, with a level of significance set at 5%. RESULTS: There was a significant association between the diagnosis of MS and NAFLD (χ² = 6.84, p = 0.01). As for the diagnostic components of MS, there was a positive and significant association between HDL-C (p = 0.05), waist circumference (p < 0.05) and hypertension (χ² = 4.195, p = 0.041) with NAFLD. HOMA-IR (p < 0.001) also showed a positive association with liver disease. CONCLUSION: A positive and significant association between NAFLD and components of metabolic syndrome in class III obese individuals was observed, suggesting the need and importance of monitoring these components for NAFLD screening.
Reference Key
chaves2012revistaassociao Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Gabriela Villaça Chaves;Daiane Spitz de Souza;Silvia Elaine Pereira;Carlos José Saboya;Wilza Arantes Ferreira Peres
Journal acta crystallographica section e
Year 2012
DOI
10.1590/S0104-42302012000300007
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302012000300007
Keywords
fatty liver metabolic syndrome x

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