pravastatin but not simvastatin improves survival and neurofunctional outcome after cardiac arrest and cardiopulmonary resuscitation
Clicks: 326
ID: 143948
2017
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
326 views
43 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #4 of 42 articles by views in journal of nuclear materials
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Summary: Cardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR) is associated with high mortality and poor neurological outcome. We compared the effects of pravastatin and simvastatin on survival and neurofunction in a murine model of CA/CPR. Pravastatin, a hydrophilic statin, increased survival and neurofunction during a 28-day follow-up period. This therapy was associated with improved pulmonary function, reduced pulmonary edema, and increased endothelial cell function in vitro. In contrast, lipophilic simvastatin did not modulate survival but increased pulmonary edema and impaired endothelial cell function. Although pravastatin may display a therapeutic option for post-CA syndrome, the application of simvastatin may require re-evaluation. Key Words: cardiac arrest, endothelial cell function, ischemia and reperfusion injury, pravastatin, resuscitation, simvastatin
Abstract Quality Issue:
This abstract appears to be incomplete or contains metadata (116 words).
Try re-searching for a better abstract.
| Reference Key |
md2017jacc:pravastatin
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Stefan Bergt, MD;Andrea Grub, MD;Steffen Wagner, MD;Hauke Engelke, MD;Gabriele Nöldge-Schomburg, MD;Brigitte Vollmar, MD;Jan P. Roesner, MD;Nana-Maria Wagner, MD |
| Journal | journal of nuclear materials |
| Year | 2017 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.