classification, molecular characterization, and the significance of pten alteration in leiomyosarcoma

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ID: 143797
2012
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Abstract
Leiomyosarcoma is a malignant smooth muscle neoplasm with a complicated histopathologic classification scheme and marked differences in clinical behavior depending on the anatomic site of origin. Overlapping morphologic features of benign and borderline malignant smooth muscle neoplasms further complicate the diagnostic process. Likewise, deciphering the complex and heterogeneous patterns of genetic changes which occur in this cancer has been challenging. Preliminary studies suggest that reproducible molecular classification may be possible in the near future and new prognostic markers are emerging. Robust recapitulation of leiomyosarcoma in mice with conditional deletion of Pten in smooth muscle and the simultaneous discovery of a novel role for Pten in genomic stability provide a fresh perspective on the mechanism of leiomyosarcomagenesis and promise for therapeutic intervention.
Reference Key
grossmann2012sarcomaclassification, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Allie H. Grossmann;Lester J. Layfield;R. Lor Randall
Journal the journal of physiology
Year 2012
DOI
10.1155/2012/380896
URL
http://dx.doi.org/10.1155/2012/380896
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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