evaluation of the biological activity of naturally occurring 5,8-dihydroxycoumarin

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ID: 143536
2013
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Abstract
5,8-Dihydroxycoumarin (5,8-DHC) was isolated from aerial parts of sweet grass (Hierochloë odorata L.) and screened for antioxidant and genotoxic activities. A clear linear dependency of radical scavenging capacity in DPPH• and ABTS•+ assays was determined. 5,8-DHC was very efficient in retarding rapeseed oil oxidation (Oxipress test). TPC (total phenols content) and FRAP (the ability to reduce ferric ion to ferrous ion) assays revealed a somewhat lower antioxidant capacity of 5,8-DHC as compared with gallic acid. Genotoxic activity was tested using different genetic end-points: chromosome aberrations (CAs) and micronuclei (MN) in Wistar rat bone marrow in vivo, CAs and sister chromatid exchanges (SCEs) in human lymphocytes in vitro, and somatic mutations and recombination in Drosophila melanogaster wing cells in vivo. 5,8-DHC did not increase frequency of CAs in rat bone marrow cells, but induced a significant increase of MN. It was slightly mutagenic in the Drosophila melanogaster assay after 120 h of treatment, but not after 48 h of treatment. 5,8-DHC induced both CAs and SCEs in vitro in human lymphocytes in a clear dose-dependent manner. Thus, 5,8-DHC may be classified as weakly genotoxic both in vivo and in vitro.
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venskutonis2013moleculesevaluation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Petras Rimantas Venskutonis;Audrius Pukalskas;Rita Kazernavičiūtė;Vaidotas Morkūnas;Jūratė Mierauskienė;Juozas R. Lazutka;Veronika Dedonytė;Gražina Slapšytė
Journal Journal of ethnopharmacology
Year 2013
DOI
10.3390/molecules18044419
URL
http://www.mdpi.com/1420-3049/18/4/4419
Keywords
5 antioxidant activity genotoxicity chromosome aberrations somatic mutation and recombinationorganic chemistry

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