moonlighting with wdr5: a cellular multitasker

Clicks: 201
ID: 143482
2018
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Ranked #60 of 79 articles by views in international journal of occupational medicine and environmental health

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Abstract
WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding component of histone methyltransferase complexes, but emerging evidence demonstrates that it does much more, ranging from expanded functions in the nucleus through to controlling the integrity of cell division. The purpose of this review is to describe the current molecular understandings of WDR5, discuss how it participates in diverse cellular processes, and highlight drug discovery efforts around WDR5 that may form the basis of new anti-cancer therapies.
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guarnaccia2018journalmoonlighting Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Alissa duPuy Guarnaccia;William Patrick Tansey
Journal international journal of occupational medicine and environmental health
Year 2018
DOI
10.3390/jcm7020021
URL
http://www.mdpi.com/2077-0383/7/2/21
Keywords
Cancer epigenetics transcription drug discoverymedicine

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