regulation of cell death in cancer – possible implications for immunotherapy

Clicks: 223
ID: 142938
2013
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Abstract
Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape. Therefore, evasion of programmed cell death may provide one possible explanation why cancer immunotherapy has so far only shown modest clinical benefits for children with cancer. A better understanding of the molecular mechanisms that regulate sensitivity and resistance to programmed cell death is expected to open new perspectives for the development of novel experimental treatment strategies to enhance the efficacy of cancer immunotherapy in the future.
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Authors ;Simone eFulda
Journal international journal of heat and technology
Year 2013
DOI
10.3389/fonc.2013.00029
URL
http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00029/full
Keywords
apoptosis immunotherapy cell death signal transduction Oncology including cancer and carcinogens tumors

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